[HTML][HTML] E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells

F Sun, MJ Hug, CM Lewarchik, CHC Yun… - Journal of Biological …, 2000 - ASBMB
Although it is generally recognized that cystic fibrosis transmembrane conductance regulator
(CFTR) contains a PSD-95/Disc-large/ZO-1 (PDZ)-binding motif at its COOH terminus, the
identity of the PDZ domain protein (s) that interact with CFTR is uncertain, and the functional
impact of this interaction is not fully understood. By using human airway epithelial cells, we
show that CFTR associates with Na+/H+ exchanger (NHE) type 3kinase Aregulatory protein
(E3KARP), an EBP50/NHE regulatory factor (NHERF)-related PDZ domain protein. The PDZ …