[HTML][HTML] Evidence against the rescue of defective ΔF508-CFTR cellular processing by curcumin in cell culture and mouse models
Y Song, ND Sonawane, D Salinas, L Qian… - Journal of Biological …, 2004 - ASBMB
Curcumin, the yellow colored component of the spice turmeric, has been reported to rescue
defective ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) cellular
processing in homozygous mutant mice, restoring nasal potential differences and improving
survival (Egan, ME, Pearson, M., Weiner, SA, Rajendran, V., Rubin, D., Glockner-Pagel, J.,
Canny, S., Du, K., Lukacs, GL, and Caplan, MJ (2004) Science 304, 600–602). Because of
the implied potential use of curcumin or similar compounds in the therapy of cystic fibrosis …
defective ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) cellular
processing in homozygous mutant mice, restoring nasal potential differences and improving
survival (Egan, ME, Pearson, M., Weiner, SA, Rajendran, V., Rubin, D., Glockner-Pagel, J.,
Canny, S., Du, K., Lukacs, GL, and Caplan, MJ (2004) Science 304, 600–602). Because of
the implied potential use of curcumin or similar compounds in the therapy of cystic fibrosis …