[HTML][HTML] Identification of the cystic fibrosis transmembrane conductance regulator domains that are important for interactions with ROMK2
P Cahill, MW Nason, C Ambrose, TY Yao… - Journal of Biological …, 2000 - ASBMB
In addition to functioning as a cAMP-activated chloride channel, the cystic fibrosis
transmembrane conductance regulator (CFTR) plays an important role in conferring
regulatory properties on other ion channels. It is known, with respect to CFTR regulation of
ROMK2 (renally derived K ATP channel), that the first transmembrane domain and the first
nucleotide binding fold domain (NBF1) of CFTR are necessary for this interaction to occur. It
has been shown that under conditions that promote phosphorylation, the ROMK2-CFTR …
transmembrane conductance regulator (CFTR) plays an important role in conferring
regulatory properties on other ion channels. It is known, with respect to CFTR regulation of
ROMK2 (renally derived K ATP channel), that the first transmembrane domain and the first
nucleotide binding fold domain (NBF1) of CFTR are necessary for this interaction to occur. It
has been shown that under conditions that promote phosphorylation, the ROMK2-CFTR …