[HTML][HTML] Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout …
M Lu, T Wang, Q Yan, X Yang, K Dong… - Journal of Biological …, 2002 - ASBMB
The ROMK (Kir1. 1; Kcnj1) gene is believed to encode the apical small conductance K+
channels (SK) of the thick ascending limb (TAL) and cortical collecting duct (CCD). Loss-of-
function mutations in the human ROMK gene cause Bartter's syndrome with renal Na+
wasting, consistent with the role of this channel in apical K+ recycling in the TAL that is
crucial for NaCl reabsorption. However, the mechanism of renal K+ wasting and
hypokalemia that develop in individuals with ROMK Bartter's syndrome is not apparent given …
channels (SK) of the thick ascending limb (TAL) and cortical collecting duct (CCD). Loss-of-
function mutations in the human ROMK gene cause Bartter's syndrome with renal Na+
wasting, consistent with the role of this channel in apical K+ recycling in the TAL that is
crucial for NaCl reabsorption. However, the mechanism of renal K+ wasting and
hypokalemia that develop in individuals with ROMK Bartter's syndrome is not apparent given …