[HTML][HTML] Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome
JN Lorenz, NR Baird, LM Judd, WT Noonan… - Journal of Biological …, 2002 - ASBMB
ROMK is an apical K+ channel expressed in the thick ascending limb of Henle (TALH) and
throughout the distal nephron of the kidney. Null mutations in theROMK gene cause type II
Bartter's syndrome, in which abnormalities of electrolyte, acid-base, and fluid-volume
homeostasis occur because of defective NaCl reabsorption in the TALH. To understand
better the pathogenesis of type II Bartter's syndrome, we developed a mouse lacking ROMK
and examined its phenotype. Young null mutants had hydronephrosis, were severely …
throughout the distal nephron of the kidney. Null mutations in theROMK gene cause type II
Bartter's syndrome, in which abnormalities of electrolyte, acid-base, and fluid-volume
homeostasis occur because of defective NaCl reabsorption in the TALH. To understand
better the pathogenesis of type II Bartter's syndrome, we developed a mouse lacking ROMK
and examined its phenotype. Young null mutants had hydronephrosis, were severely …