Nitric oxide therapy in sickle cell disease
MT Gladwin, AN Schechter - Seminars in hematology, 2001 - Elsevier
Recent clinical and experimental data suggest that nitric oxide (NO) may play a role in the
pathogenesis and therapy of sickle cell disease. NO, a soluble gas continuously synthesized
in endothelial cells by the NO synthase (NOS) enzyme systems, regulates basal vascular
tone and endothelial function, and maintains blood oxygenation via hypoxic pulmonary
vasoconstriction and reduced shunt physiology. These vital homeostatic processes may be
impaired in sickle cell disease and contribute to its pathogenesis. Therapeutic NO inhalation …
pathogenesis and therapy of sickle cell disease. NO, a soluble gas continuously synthesized
in endothelial cells by the NO synthase (NOS) enzyme systems, regulates basal vascular
tone and endothelial function, and maintains blood oxygenation via hypoxic pulmonary
vasoconstriction and reduced shunt physiology. These vital homeostatic processes may be
impaired in sickle cell disease and contribute to its pathogenesis. Therapeutic NO inhalation …