α4 Integrins as Therapeutic Targets in Autoimmune Disease
UH von Andrian, B Engelhardt - New England Journal of …, 2003 - Mass Medical Soc
New England Journal of Medicine, 2003•Mass Medical Soc
In this issue of the Journal, two groups of investigators report on clinical trials of natalizumab,
a recombinant monoclonal antibody against α4 integrins, for the treatment of multiple
sclerosis1 and Crohn's disease. 2 Miller et al. report that a group of patients with multiple
sclerosis who received monthly injections of natalizumab had significantly fewer new
inflammatory central nervous system lesions than the placebo group (a reduction of
approximately 90 percent) and had approximately half as many clinical relapses. 1 Ghosh et …
a recombinant monoclonal antibody against α4 integrins, for the treatment of multiple
sclerosis1 and Crohn's disease. 2 Miller et al. report that a group of patients with multiple
sclerosis who received monthly injections of natalizumab had significantly fewer new
inflammatory central nervous system lesions than the placebo group (a reduction of
approximately 90 percent) and had approximately half as many clinical relapses. 1 Ghosh et …
In this issue of the Journal, two groups of investigators report on clinical trials of natalizumab, a recombinant monoclonal antibody against α4 integrins, for the treatment of multiple sclerosis1 and Crohn's disease.2 Miller et al. report that a group of patients with multiple sclerosis who received monthly injections of natalizumab had significantly fewer new inflammatory central nervous system lesions than the placebo group (a reduction of approximately 90 percent) and had approximately half as many clinical relapses.1 Ghosh et al. report that patients with Crohn's disease also had an improved response to natalizumab,2 with response and remission rates that . . .
The New England Journal Of Medicine