[HTML][HTML] A fragment of Paxillin binds the α4Integrin cytoplasmic domain (tail) and selectively inhibits α4-mediated cell migration
S Liu, WB Kiosses, DM Rose, M Slepak… - Journal of Biological …, 2002 - ASBMB
The α 4 integrins play important roles in embryogenesis, hematopoiesis, cardiac
development, and the immune responses. The α 4 integrin subunit is indispensable for
these biological processes, possibly because the α 4 subunit regulates cellular functions
differently from other integrin α subunits. We have previously reported that the α 4
cytoplasmic domain directly and tightly binds paxillin, an intracellular signaling adaptor
molecule, and this interaction accounts for some of the unusual functional responses to α 4 …
development, and the immune responses. The α 4 integrin subunit is indispensable for
these biological processes, possibly because the α 4 subunit regulates cellular functions
differently from other integrin α subunits. We have previously reported that the α 4
cytoplasmic domain directly and tightly binds paxillin, an intracellular signaling adaptor
molecule, and this interaction accounts for some of the unusual functional responses to α 4 …