[HTML][HTML] Making a bad thing worse: adverse effects of stress on drug addiction
JN Cleck, JA Blendy - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
JN Cleck, JA Blendy
The Journal of clinical investigation, 2008•Am Soc Clin InvestigSustained exposure to various psychological stressors can exacerbate neuropsychiatric
disorders, including drug addiction. Addiction is a chronic brain disease in which individuals
cannot control their need for drugs, despite negative health and social consequences. The
brains of addicted individuals are altered and respond very differently to stress than those of
individuals who are not addicted. In this Review, we highlight some of the common effects of
stress and drugs of abuse throughout the addiction cycle. We also discuss both animal and …
disorders, including drug addiction. Addiction is a chronic brain disease in which individuals
cannot control their need for drugs, despite negative health and social consequences. The
brains of addicted individuals are altered and respond very differently to stress than those of
individuals who are not addicted. In this Review, we highlight some of the common effects of
stress and drugs of abuse throughout the addiction cycle. We also discuss both animal and …
Sustained exposure to various psychological stressors can exacerbate neuropsychiatric disorders, including drug addiction. Addiction is a chronic brain disease in which individuals cannot control their need for drugs, despite negative health and social consequences. The brains of addicted individuals are altered and respond very differently to stress than those of individuals who are not addicted. In this Review, we highlight some of the common effects of stress and drugs of abuse throughout the addiction cycle. We also discuss both animal and human studies that suggest treating the stress-related aspects of drug addiction is likely to be an important contributing factor to a long-lasting recovery from this disorder.
The Journal of Clinical Investigation