Rapid disease progression correlates with instability of mutant SOD1 in familial ALS
T Sato, T Nakanishi, Y Yamamoto, PM Andersen… - Neurology, 2005 - AAN Enterprises
T Sato, T Nakanishi, Y Yamamoto, PM Andersen, Y Ogawa, K Fukada, Z Zhou, F Aoike…
Neurology, 2005•AAN EnterprisesStudies on the clinical course of familial ALS suggest that the duration of illness is relatively
consistent for each mutation but variable among the different mutations. The authors
analyzed the relative amount of mutant compared with normal SOD1 protein in the
erythrocytes from 29 patients with ALS with 22 different mutations. Turnover of mutant SOD1
correlated with a shorter disease survival time.
consistent for each mutation but variable among the different mutations. The authors
analyzed the relative amount of mutant compared with normal SOD1 protein in the
erythrocytes from 29 patients with ALS with 22 different mutations. Turnover of mutant SOD1
correlated with a shorter disease survival time.
Studies on the clinical course of familial ALS suggest that the duration of illness is relatively consistent for each mutation but variable among the different mutations. The authors analyzed the relative amount of mutant compared with normal SOD1 protein in the erythrocytes from 29 patients with ALS with 22 different mutations. Turnover of mutant SOD1 correlated with a shorter disease survival time.
American Academy of Neurology