PIPkins, their substrates and their products: new functions for old enzymes
KA Hinchliffe, A Ciruela, RF Irvine - … Acta (BBA)-Molecular and Cell Biology …, 1998 - Elsevier
The phosphatidylinositolphosphate kinases (PIPkins) are a unique family of enzymes that
catalyse the production of phosphorylated inositol lipids. Recent advances have revealed
that, due to their ability to utilise a number of different lipid substrates (at least in vitro), this
family is potentially able to generate several distinct, physiologically important inositol lipids.
Despite their importance, however, our understanding of the regulation of the PIPkins and of
their physiological role in cellular signalling and regulation is still poor. Here we describe in …
catalyse the production of phosphorylated inositol lipids. Recent advances have revealed
that, due to their ability to utilise a number of different lipid substrates (at least in vitro), this
family is potentially able to generate several distinct, physiologically important inositol lipids.
Despite their importance, however, our understanding of the regulation of the PIPkins and of
their physiological role in cellular signalling and regulation is still poor. Here we describe in …