Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases
YS Mao, HL Yin - Pflügers Archiv-European Journal of Physiology, 2007 - Springer
YS Mao, HL Yin
Pflügers Archiv-European Journal of Physiology, 2007•SpringerAbstract Phosphatidylinositol (4, 5)-bisphosphate (PIP 2) is an important lipid mediator that
has multiple regulatory functions. There is now increasing evidence that the
phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP 2, are regulated
spatially and temporally and that they have isoform-specific functions and regulations. This
review will summarize the highlights of recent developments in understanding how the three
major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
has multiple regulatory functions. There is now increasing evidence that the
phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP 2, are regulated
spatially and temporally and that they have isoform-specific functions and regulations. This
review will summarize the highlights of recent developments in understanding how the three
major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
Abstract
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
Springer