[HTML][HTML] Type I phosphatidylinositol-4-phosphate 5-kinases: cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family

H Ishihara, Y Shibasaki, N Kizuki, T Wada… - Journal of Biological …, 1998 - ASBMB
Type I phosphatidylinositol 4-phosphate (PtdIns (4) P) 5-kinases (PIP5K) catalyze the
synthesis of phosphatidylinositol 4, 5-bisphosphate, an essential lipid molecule in various
cellular processes. Here, we report the cloning of the third member (PIP5Kγ) and the
characterization of members of the type I PIP5K family. Type I PIP5Kγ has two alternative
splicing forms, migrating at 87 and 90 kDa on SDS-polyacrylamide gel electrophoresis. The
amino acid sequence of the central portion of this isoform shows approximately 80% identity …