[HTML][HTML] Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family
JC Loijens, RA Anderson - Journal of Biological Chemistry, 1996 - ASBMB
Phosphatidylinositol-4-phosphate 5-kinases (PIP5K) synthesize phosphatidylinositol-4, 5-
bisphosphate, a key precursor in phosphoinositide signaling that also regulates some
proteins and cellular processes directly. Two distinct PIP5Ks have been characterized in
erythrocytes, the 68-kDa type I (PIP5KI) and 53-kDa type II (PIP5KII) isoforms. Using peptide
sequences from the erythroid 68-kDa PIP5KI, we have isolated cDNAs encoding PIP5KIα
from human brain. Partial cDNAs obtained for a second isoform, PIP5KIβ, established that …
bisphosphate, a key precursor in phosphoinositide signaling that also regulates some
proteins and cellular processes directly. Two distinct PIP5Ks have been characterized in
erythrocytes, the 68-kDa type I (PIP5KI) and 53-kDa type II (PIP5KII) isoforms. Using peptide
sequences from the erythroid 68-kDa PIP5KI, we have isolated cDNAs encoding PIP5KIα
from human brain. Partial cDNAs obtained for a second isoform, PIP5KIβ, established that …