Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS
KL Ferrante, J Shefner, H Zhang, R Betensky… - Neurology, 2005 - AAN Enterprises
Neurology, 2005•AAN Enterprises
An open-label dose-escalation trial was performed to assess the safety and tolerability of
high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron
transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe
and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.
high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron
transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe
and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.
An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subjects treated with doses as high as 3,000 mg/day for 8 months.
American Academy of Neurology