[HTML][HTML] Nox1-dependent reactive oxygen generation is regulated by Rac1
G Cheng, BA Diebold, Y Hughes… - Journal of Biological …, 2006 - ASBMB
Rac1 has been implicated in the generation of reactive oxygen species (ROS) in several cell
types, but the enzymatic origin of the ROS has not been proven. The present studies
demonstrate that Nox1, a homolog of the phagocyte NADPH-oxidase component gp91
phox, is activated by Rac1. When Nox1 is co-expressed along with its regulatory subunits
NOXO1 and NOXA1, significant ROS generation is seen. Herein, co-expression of
constitutively active Rac1 (G12V), but not wild-type Rac1, resulted in marked further …
types, but the enzymatic origin of the ROS has not been proven. The present studies
demonstrate that Nox1, a homolog of the phagocyte NADPH-oxidase component gp91
phox, is activated by Rac1. When Nox1 is co-expressed along with its regulatory subunits
NOXO1 and NOXA1, significant ROS generation is seen. Herein, co-expression of
constitutively active Rac1 (G12V), but not wild-type Rac1, resulted in marked further …