Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking
S Erb, PK Hitchcott, H Rajabi, D Mueller… - …, 2000 - Elsevier
The alpha-2 adrenergic receptor agonists, clonidine, lofexidine and guanabenz, blocked
stress-but not cocaine-induced reinstatement of cocaine seeking at doses that suppressed
footshock-induced release of noradrenaline in prefrontal cortex and amygdala. Rats were
trained to self-administer cocaine (0.5 mg/kg/infusion, iv; 10–12 days) and, after a drug-free
period (7–13 days), were returned to the self-administration chambers for daily extinction
and reinstatement test sessions. Both intermittent footshock (15 min, 0.6 mA) and cocaine …
stress-but not cocaine-induced reinstatement of cocaine seeking at doses that suppressed
footshock-induced release of noradrenaline in prefrontal cortex and amygdala. Rats were
trained to self-administer cocaine (0.5 mg/kg/infusion, iv; 10–12 days) and, after a drug-free
period (7–13 days), were returned to the self-administration chambers for daily extinction
and reinstatement test sessions. Both intermittent footshock (15 min, 0.6 mA) and cocaine …