Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets
SD Dreyer, T Naruse, R Morello, B Zabel… - Gene expression …, 2004 - Elsevier
The tetrapod limb exhibits distinct dorsoventral joint, tendon, and muscle asymmetry. The
LIM-homeodomain transcription factor, Lmx1b, is required to achieve the dorsal character of
these structures, but the mechanism by which Lmx1b orchestrates this asymmetrical
development is unknown. To identify target tissues and genes regulated by Lmx1b, we
examined Lmx1b expression during joint, tendon and muscle formation (9.5–16.5 dpc) and
the expression of several genes spatially restricted to developing joints and associated …
LIM-homeodomain transcription factor, Lmx1b, is required to achieve the dorsal character of
these structures, but the mechanism by which Lmx1b orchestrates this asymmetrical
development is unknown. To identify target tissues and genes regulated by Lmx1b, we
examined Lmx1b expression during joint, tendon and muscle formation (9.5–16.5 dpc) and
the expression of several genes spatially restricted to developing joints and associated …