Unique lipoproteins secreted by primary astrocytes from wild type, apoE (−/−), and human apoE transgenic mice
AM Fagan, DM Holtzman, G Munson, T Mathur… - Journal of Biological …, 1999 - ASBMB
Composition of central nervous system lipoproteins affects the metabolism of lipoprotein
constituents within the brain. The ε4 allele of apolipoprotein E (apoE) is a risk factor for
Alzheimer's disease via an unknown mechanism (s). As glia are the primary central nervous
system cell type that synthesize apoE, we characterized lipoproteins secreted by astrocytes
from wild type (WT), apoE (−/−), and apoE transgenic mice expressing human apoE3 or
apoE4 in a mouseapoE (−/−) background. Nondenaturing size exclusion chromatography …
constituents within the brain. The ε4 allele of apolipoprotein E (apoE) is a risk factor for
Alzheimer's disease via an unknown mechanism (s). As glia are the primary central nervous
system cell type that synthesize apoE, we characterized lipoproteins secreted by astrocytes
from wild type (WT), apoE (−/−), and apoE transgenic mice expressing human apoE3 or
apoE4 in a mouseapoE (−/−) background. Nondenaturing size exclusion chromatography …
