[HTML][HTML] Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter …

V Bocher, ER James, SM Clee, LH Zhang… - Journal of biological …, 2001 - ASBMB
By using BAC transgenic mice, we have shown that increased human ABCA1 protein
expression results in a significant increase in cholesterol efflux in different tissues and
marked elevation in high density lipoprotein (HDL)-cholesterol levels associated with
increases in apoAI and apoAII. Three novel ABCA1transcripts containing three different
transcription initiation sites that utilize sequences in intron 1 have been identified. In BAC
transgenic mice there is an increased expression of ABCA1 protein, but the distribution of …