[PDF][PDF] Osteocyte messages from a bony tomb
LF Bonewald - Cell metabolism, 2007 - cell.com
Cell metabolism, 2007•cell.com
Until recently, osteocytes have escaped the limelight, embedded within their cave-like
lacunae in the mineralized matrix of bone. In this issue of Cell Metabolism, Tatsumi et
al.(2007) present evidence that this" third bone cell" can send either inhibitory signals to
osteoclasts to maintain bone mass with normal loading or stimulatory signals to osteoclasts
to initiate bone loss upon immobilization, thereby playing an indispensable role in skeletal
homeostasis.
lacunae in the mineralized matrix of bone. In this issue of Cell Metabolism, Tatsumi et
al.(2007) present evidence that this" third bone cell" can send either inhibitory signals to
osteoclasts to maintain bone mass with normal loading or stimulatory signals to osteoclasts
to initiate bone loss upon immobilization, thereby playing an indispensable role in skeletal
homeostasis.
Until recently, osteocytes have escaped the limelight, embedded within their cave-like lacunae in the mineralized matrix of bone. In this issue of Cell Metabolism, Tatsumi et al. (2007) present evidence that this "third bone cell" can send either inhibitory signals to osteoclasts to maintain bone mass with normal loading or stimulatory signals to osteoclasts to initiate bone loss upon immobilization, thereby playing an indispensable role in skeletal homeostasis.
cell.com