Mechanical stimulation in vivo reduces osteocyte expression of sclerostin
AG Robling, T Bellido, CH Turner - Journal of Musculoskeletal and …, 2006 - ismni.org
Mechanical stimulation in vivo reduces osteocyte expression of sclerostin Page 1 354
Osteocytes are by far the most numerous cell type in bone. Their population density, distribution,
extensive communication networks, and fluid-filled lacuno-canalicular environment make these
cells ideal mechanosensors in bone’s adaptive process. Despite these attributes, very little data
have been generated that implicate the osteocyte network as the primary mechanosensory
cell type, to the exclusion of the other cell types (eg, osteoblasts, bone lining cells). The …
Osteocytes are by far the most numerous cell type in bone. Their population density, distribution,
extensive communication networks, and fluid-filled lacuno-canalicular environment make these
cells ideal mechanosensors in bone’s adaptive process. Despite these attributes, very little data
have been generated that implicate the osteocyte network as the primary mechanosensory
cell type, to the exclusion of the other cell types (eg, osteoblasts, bone lining cells). The …