[HTML][HTML] Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines
Considerable controversy exists in determining the role of peroxisome proliferator-activated
receptor-α (PPARα) in obesity. Two purebred congenic strains of PPARα-null mice were
developed to study the role of this receptor in modulating lipid transport and storage. Weight
gain and average body weight in wild-type and PPARα-null mice on either an Sv/129 or a
C57BL/6N background were not markedly different between genotypes from 3 to 9 months
of age. However, gonadal adipose stores were significantly greater in both strains of male …
receptor-α (PPARα) in obesity. Two purebred congenic strains of PPARα-null mice were
developed to study the role of this receptor in modulating lipid transport and storage. Weight
gain and average body weight in wild-type and PPARα-null mice on either an Sv/129 or a
C57BL/6N background were not markedly different between genotypes from 3 to 9 months
of age. However, gonadal adipose stores were significantly greater in both strains of male …