Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules
T Oikawa, H Ojima, S Yamasaki, T Takayama… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Histological observations support the concept of multistep and
multicentric development of hepatocellular carcinoma (HCC) in cases of chronic liver
disease. However, the relationship between the incidence of such a modality of
development of HCC and the type of background liver disease has not been fully
investigated. METHODS: A total of 980 HCC nodules resected from 664 patients were
analyzed. Multistep HCC was defined as well differentiated HCC containing the portal tracts …
multicentric development of hepatocellular carcinoma (HCC) in cases of chronic liver
disease. However, the relationship between the incidence of such a modality of
development of HCC and the type of background liver disease has not been fully
investigated. METHODS: A total of 980 HCC nodules resected from 664 patients were
analyzed. Multistep HCC was defined as well differentiated HCC containing the portal tracts …