Intravital microscopy (IVM) enables the study of cellular and molecular events in living organisms. Confocal microscopy permits images to be collected from narrow focal planes without interference from out-of-focus regions, and multi-photon microscopy produces high-resolution images from deep (several hundred micrometers) within opaque organs and tissues. Lasers that are targeted through microscope objectives can injure individual microvessels and induce thrombi that can be studied in detail. The marriage of these technologies provides exciting possibilities for investigating the inflammation and coagulation that is associated with disseminated intravascular coagulation (DIC). In this review, I consider some of the new technology associated with microscopy, give examples of discoveries that have been made using this technology and speculate on how the study of DIC might be advanced using IVM.