Adipose tissue blood flow was measured in six healthy, non‐obese subjects with the xenon wash‐out technique after labelling of the tissue by either injection of ¹³³Xe dissolved in isotonic sodium chloride (water depot) or injection of ¹³³Xe in gas form (gas depot). The wash‐out rates were registered from four depots simultaneously. Two depots were placed above the umbilicus, and two depots were placed below the umbilicus in the abdominal, subcutaneous adipose tissue. A water depot and a gas depot were placed in the two positions, respectively. It was not possible to demonstrate any difference between the wash‐out rates registered from the two depot types, and it was also not possible to demonstrate any difference between the changes in wash‐out rates induced by an oral glucose load. Similarly, the tissue distribution of the water and the gas depots appeared to be similar as registered by a gamma camera. It is concluded that that the two tissue labelling modes give identical results. However, there are significant regional differences in the wash‐out rates of xenon from subcutaneous, abdominal adipose tissue, the wash‐out rates from infraumbilical depots being about 20% lower than from the supraumbilical depots.