R1615P: a novel mutation in ABCA1 associated with low levels of HDL and type II diabetes mellitus
D Saleheen, A Nazir, S Khanum… - International …, 2006 - internationaljournalofcardiology.com
Low levels of high density lipoprotein-cholesterol (HDL-C) is an established risk factor for
cardiovascular disorders and is independent of LDL and total cholesterol concentration in
predicting the risk of disease [1]. The protective effect of HDL-C is mediated by its role in
maintaining tight regulation between the forward and reverse cholesterol transport system,
preserving endothelial function, preventing LDL oxidation and stabilizing its own integrity
through its various associated enzymes [2]. Family and twin studies have shown that about …
cardiovascular disorders and is independent of LDL and total cholesterol concentration in
predicting the risk of disease [1]. The protective effect of HDL-C is mediated by its role in
maintaining tight regulation between the forward and reverse cholesterol transport system,
preserving endothelial function, preventing LDL oxidation and stabilizing its own integrity
through its various associated enzymes [2]. Family and twin studies have shown that about …