[HTML][HTML] Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
M Shimabukuro, YT Zhou, Y Lee, RH Unger - Journal of Biological …, 1998 - ASBMB
The thiazolidinedione compound troglitazone, which is used to treat non-insulin-dependent
diabetes mellitus (NIDDM) in man, is also effective in the adipogenic NIDDM of Zucker
diabetic fatty (ZDF) rats. To test the" lipotoxicity hypothesis," which attributes the beta cell
dysfunction of adipogenic NIDDM to an excessive accumulation of fat in the pancreatic
islets, we sought to determine if troglitazone-mediated amelioration of beta cell function in
islets of ZDF rats might be associated with a reduction in their elevated triglyceride (TG) …
diabetes mellitus (NIDDM) in man, is also effective in the adipogenic NIDDM of Zucker
diabetic fatty (ZDF) rats. To test the" lipotoxicity hypothesis," which attributes the beta cell
dysfunction of adipogenic NIDDM to an excessive accumulation of fat in the pancreatic
islets, we sought to determine if troglitazone-mediated amelioration of beta cell function in
islets of ZDF rats might be associated with a reduction in their elevated triglyceride (TG) …