Pathogenesis and therapy of psoriasis

MA Lowes, AM Bowcock, JG Krueger - Nature, 2007 - nature.com
MA Lowes, AM Bowcock, JG Krueger
Nature, 2007nature.com
Psoriasis is one of the most common human skin diseases and is considered to have key
genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of
keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte
response is thought to be activation of the cellular immune system, with T cells, dendritic
cells and various immune-related cytokines and chemokines implicated in pathogenesis.
The newest therapies for psoriasis target its immune components and may predict potential …
Abstract
Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.
nature.com