Early IL-4 Production Does Not Predict Susceptibility toLeishmania major

P Scott, A Eaton, WC Gause, X di Zhou… - Experimental …, 1996 - Elsevier
Leishmania majorin mice can be self-limiting or fatal, depending upon the inbred mouse
strain. It is well established that the outcome of infection is dependent upon the Th cell
subset that dominates after infection. This has led to intense study of the early events
associated with infection, in order to better understand the factors that determine Th1/2 cell
development. In the present report, we have analyzed the kinetics of IL-4 and IL-4 mRNA
production in three mouse strains: BALB/c, C3H, and C57BL/6. We found that in the first …