[HTML][HTML] Functional modulation of the glucocorticoid receptor and suppression of NF-κB-dependent transcription by ursodeoxycholic acid
T Miura, R Ouchida, N Yoshikawa, K Okamoto… - Journal of Biological …, 2001 - ASBMB
Ursodeoxycholic acid (UDCA) is the current mainstay of treatment for various liver diseases
including primary biliary cirrhosis. UDCA acts as a bile secretagogue, cytoprotective agent,
immunomodulator, and inhibitor of cellular apoptosis. Despite this cumulative evidence of
the cytoprotective and immunosuppressive effects of UDCA, both the target molecule and
pathway of UDCA action remain unknown. We previously described that, in the absence of
glucocorticoid ligand, UDCA activates the glucocorticoid receptor (GR) into DNA binding …
including primary biliary cirrhosis. UDCA acts as a bile secretagogue, cytoprotective agent,
immunomodulator, and inhibitor of cellular apoptosis. Despite this cumulative evidence of
the cytoprotective and immunosuppressive effects of UDCA, both the target molecule and
pathway of UDCA action remain unknown. We previously described that, in the absence of
glucocorticoid ligand, UDCA activates the glucocorticoid receptor (GR) into DNA binding …