[HTML][HTML] Re-examination of the Role of Suppressor of Cytokine Signaling 1 (SOCS1) in the Regulation of Toll-like Receptor Signaling*♦
Suppressor of cytokine signaling 1 (SOCS1) is an obligate negative regulator of cytokine
signaling and most importantly in vivo, signaling via the interferon-γ (IFN-γ) receptor.
SOCS1, via its Src homology 2 domain, binds to phosphotyrosine residues in its targets,
reducing the amplitude of signaling from cytokine receptors. SOCS1 is also implicated in
blocking Toll-like receptor (TLR) signaling in macrophages activated by TLR agonists such
as lipopolysaccharide (LPS), thus regulating multiple steps in the activation of innate …
signaling and most importantly in vivo, signaling via the interferon-γ (IFN-γ) receptor.
SOCS1, via its Src homology 2 domain, binds to phosphotyrosine residues in its targets,
reducing the amplitude of signaling from cytokine receptors. SOCS1 is also implicated in
blocking Toll-like receptor (TLR) signaling in macrophages activated by TLR agonists such
as lipopolysaccharide (LPS), thus regulating multiple steps in the activation of innate …