[HTML][HTML] Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells: ubiquitin/proteasome-dependent regulation
Y Tintut, F Parhami, V Le, G Karsenty… - Journal of Biological …, 1999 - ASBMB
The cAMP pathway, a major intracellular pathway mediating parathyroid hormone signal,
regulates osteoblastic function. Parathyroid hormone (through activation of protein kinase A)
has also been shown to stimulate ubiquitin/proteasome activity in osteoblasts. Since the
osteoblast-specific transcription factor Osf2/Cbfa1 is important for differentiation of
osteoblastic cells, we examined the roles of the cAMP and ubiquitin/proteasome pathways in
regulation of Cbfa1. In the osteoblastic cell line, MC3T3-E1, continuous treatment with cAMP …
regulates osteoblastic function. Parathyroid hormone (through activation of protein kinase A)
has also been shown to stimulate ubiquitin/proteasome activity in osteoblasts. Since the
osteoblast-specific transcription factor Osf2/Cbfa1 is important for differentiation of
osteoblastic cells, we examined the roles of the cAMP and ubiquitin/proteasome pathways in
regulation of Cbfa1. In the osteoblastic cell line, MC3T3-E1, continuous treatment with cAMP …