[HTML][HTML] Protein phosphatase 2A and protein kinase Cα are physically associated and are involved in Pseudomonas aeruginosa-induced interleukin 6 production by …
RTM Boudreau, R Garduno, TJ Lin - Journal of Biological Chemistry, 2002 - ASBMB
Pulmonary infection with Pseudomonas aeruginosa is characterized by massive airway
inflammation, which comprises significant cytokine production. Although mast cells are
abundant in the lung and are potent sources of various cytokines, a role of mast cells in P.
aeruginosa infection remains undefined, and P. aeruginosa-induced signaling mechanisms
in mast cells have not been studied previously. Here we demonstrate that human cord blood-
derived mast cells, mouse bone marrow-derived mast cells, and the mouse mast cell line …
inflammation, which comprises significant cytokine production. Although mast cells are
abundant in the lung and are potent sources of various cytokines, a role of mast cells in P.
aeruginosa infection remains undefined, and P. aeruginosa-induced signaling mechanisms
in mast cells have not been studied previously. Here we demonstrate that human cord blood-
derived mast cells, mouse bone marrow-derived mast cells, and the mouse mast cell line …