[HTML][HTML] Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase

DP Mohapatra, C Nau - Journal of Biological Chemistry, 2005 - ASBMB
The vanilloid receptor TRPV1 is a polymodal nonselective cation channel of nociceptive
sensory neurons involved in the perception of inflammatory pain. TRPV1 exhibits
desensitization in a Ca 2+-dependent manner upon repeated activation by capsaicin or
protons. The cAMP-dependent protein kinase (PKA) decreases desensitization of TRPV1 by
directly phosphorylating the channel presumably at sites Ser 116 and Thr 370. In the present
study we investigated the influence of protein phosphatase 2B (calcineurin) on Ca 2+ …