[HTML][HTML] Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cε and identification of two target serine residues
M Numazaki, T Tominaga, H Toyooka… - Journal of Biological …, 2002 - ASBMB
The capsaicin receptor, VR1, is a sensory neuron-specific ion channel that serves as a
polymodal detector of pain-producing chemical and physical stimuli. It has been reported
that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by
capsaicin or protons and reduces the temperature threshold for activation of VR1 through
metabotropic P2Y 1 receptors in a protein Kinase C (PKC)-dependent pathway, suggesting
the phosphorylation of VR1 by PKC. In this study, direct phosphorylation of VR1 upon …
polymodal detector of pain-producing chemical and physical stimuli. It has been reported
that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by
capsaicin or protons and reduces the temperature threshold for activation of VR1 through
metabotropic P2Y 1 receptors in a protein Kinase C (PKC)-dependent pathway, suggesting
the phosphorylation of VR1 by PKC. In this study, direct phosphorylation of VR1 upon …