[HTML][HTML] Molecular determinants of vanilloid sensitivity in TRPV1

NR Gavva, L Klionsky, Y Qu, L Shi, R Tamir… - Journal of biological …, 2004 - ASBMB
Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the
pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia
resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and
proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine,
and products of lipoxygenase). Only limited information is available in TRPV1 on the
residues that contribute to vanilloid activation. Interestingly, rabbits have been suggested to …