[HTML][HTML] Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: a novel regulatory mechanism altered in obesity
D Bach, S Pich, FX Soriano, N Vega… - Journal of Biological …, 2003 - ASBMB
In many cells and specially in muscle, mitochondria form elongated filaments or a branched
reticulum. We show that Mfn2 (mitofusin 2), a mitochondrial membrane protein that
participates in mitochondrial fusion in mammalian cells, is induced during myogenesis and
contributes to the maintenance and operation of the mitochondrial network. Repression of
Mfn2 caused morphological and functional fragmentation of the mitochondrial network into
independent clusters. Concomitantly, repression of Mfn2 reduced glucose oxidation …
reticulum. We show that Mfn2 (mitofusin 2), a mitochondrial membrane protein that
participates in mitochondrial fusion in mammalian cells, is induced during myogenesis and
contributes to the maintenance and operation of the mitochondrial network. Repression of
Mfn2 caused morphological and functional fragmentation of the mitochondrial network into
independent clusters. Concomitantly, repression of Mfn2 reduced glucose oxidation …