Chemokines, a large family of inflammatory cytokines, have been shown to play a critical
role in the regulation of angiogenesis during several pathophysiologic processes, such as
tumor growth, wound healing and ischemia. Semiquantitative or quantitative angiogenesis
assays are commonly utilized to screen the angiogenic or angiostatic activity of chemokines.
These include in vitro endothelial cell activation assays and ex vivo or in vivo models of
neovascularization. Chemokines may exert their regulatory activity on angiogenesis directly …