Cyclooxygenase-2: a therapeutic target in angiogenesis

MA Iņiguez, A Rodrı́guez, OV Volpert, M Fresno… - Trends in molecular …, 2003 - cell.com
MA Iņiguez, A Rodrı́guez, OV Volpert, M Fresno, JM Redondo
Trends in molecular medicine, 2003cell.com
Angiogenesis has a role in the pathogenesis of several disorders, including cancer, chronic
inflammatory diseases and retinopathies. Recent evidence demonstrates that the production
of prostanoids by cyclooxygenase-2 (COX-2) promotes the expression of pro-angiogenic
factors. Furthermore, inhibition of COX-2 by non-steroidal anti-inflammatory drugs leads to
restricted angiogenesis and downregulated production of pro-angiogenic factors, such as
vascular endothelial growth factor and basic fibroblast growth factor. These findings suggest …
Abstract
Angiogenesis has a role in the pathogenesis of several disorders, including cancer, chronic inflammatory diseases and retinopathies. Recent evidence demonstrates that the production of prostanoids by cyclooxygenase-2 (COX-2) promotes the expression of pro-angiogenic factors. Furthermore, inhibition of COX-2 by non-steroidal anti-inflammatory drugs leads to restricted angiogenesis and downregulated production of pro-angiogenic factors, such as vascular endothelial growth factor and basic fibroblast growth factor. These findings suggest that COX enzymes could be important therapeutic targets in the treatment of pathological angiogenesis.
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