Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
J Mimura, M Ema, K Sogawa… - Genes & …, 1999 - genesdev.cshlp.org
J Mimura, M Ema, K Sogawa, Y Fujii-Kuriyama
Genes & development, 1999•genesdev.cshlp.orgAh receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of
environmental pollutants such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on host animals. In
addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to
activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR
function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence.
Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway …
environmental pollutants such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on host animals. In
addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to
activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR
function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence.
Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway …
Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.
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