[HTML][HTML] Immortalized mouse mammary fibroblasts lacking dioxin receptor have impaired tumorigenicity in a subcutaneous mouse xenograft model
S Mulero-Navarro, E Pozo-Guisado… - Journal of Biological …, 2005 - ASBMB
Although the dioxin receptor, the aryl hydrocarbon receptor (AhR), is considered a major
regulator of xenobiotic-induced carcinogenesis, its role in tumor formation in the absence of
xenobiotics is still largely unknown. Trying to address this question, we have produced
immortalized cell lines from wild-type (T-FGM-AhR+/+) and mutant (T-FGM-AhR-/-) mouse
mammary fibroblasts by stable co-transfection with the simian virus 40 (SV-40) large T
antigen and proto-oncogenic cH-Ras. Both cell lines had a myofibroblast phenotype and …
regulator of xenobiotic-induced carcinogenesis, its role in tumor formation in the absence of
xenobiotics is still largely unknown. Trying to address this question, we have produced
immortalized cell lines from wild-type (T-FGM-AhR+/+) and mutant (T-FGM-AhR-/-) mouse
mammary fibroblasts by stable co-transfection with the simian virus 40 (SV-40) large T
antigen and proto-oncogenic cH-Ras. Both cell lines had a myofibroblast phenotype and …