[HTML][HTML] Phosphorylation of the catalyic α-subunit constitutes a triggering signal for Na+, K+-ATPase endocytosis
AV Chibalin, CH Pedemonte, AI Katz, E Féraille… - Journal of Biological …, 1998 - ASBMB
Inhibition of Na+, K+-ATPase activity by dopamine is an important mechanism by which
renal tubules modulate urine sodium excretion during a high salt diet. However, the
molecular mechanisms of this regulation are not clearly understood. Inhibition of Na+, K+-
ATPase activity in response to dopamine is associated with endocytosis of its α-and β-
subunits, an effect that is protein kinase C-dependent. In this study we used isolated
proximal tubule cells and a cell line derived from opossum kidney and demonstrate that …
renal tubules modulate urine sodium excretion during a high salt diet. However, the
molecular mechanisms of this regulation are not clearly understood. Inhibition of Na+, K+-
ATPase activity in response to dopamine is associated with endocytosis of its α-and β-
subunits, an effect that is protein kinase C-dependent. In this study we used isolated
proximal tubule cells and a cell line derived from opossum kidney and demonstrate that …