[HTML][HTML] Appropriate polarization following pharmacological rescue of V2 vasopressin receptors encoded by X-linked nephrogenic diabetes insipidus alleles involves …
CM Tan, HH Nickols, LE Limbird - Journal of Biological Chemistry, 2003 - ASBMB
To understand the mechanisms of G protein-coupled receptor delivery and steady state
localization, we examined the trafficking itineraries of wild type (WT) and mutant V2
vasopressin receptors (V2Rs) in polarized Madin-Darby canine kidney II (MDCK II) cells and
in COS M6 cells; the mutant V2Rs represent selected alleles responsible for X-linked
nephrogenic diabetes insipidus. The WT V2R is localized on the plasma membrane and
mediates arginine vasopressin (AVP)-stimulated cAMP accumulation, whereas the clinically …
localization, we examined the trafficking itineraries of wild type (WT) and mutant V2
vasopressin receptors (V2Rs) in polarized Madin-Darby canine kidney II (MDCK II) cells and
in COS M6 cells; the mutant V2Rs represent selected alleles responsible for X-linked
nephrogenic diabetes insipidus. The WT V2R is localized on the plasma membrane and
mediates arginine vasopressin (AVP)-stimulated cAMP accumulation, whereas the clinically …