Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes
Y Fang, SI Han, C Mitchell, S Gupta, E Studer… - Hepatology, 2004 - journals.lww.com
Previous studies have demonstrated in hepatocytes that deoxycholic acid (DCA) promotes
inactivation of protein tyrosine phosphatases (PTPases) and activation of ERBB1 and the
extracellular-regulated kinase (ERK) 1/2 pathway. The present studies have determined the
biochemical mechanism (s) through which these events occur. DCA and taurodeoxycholic
acid (TDCA)(100 μmol/L) caused activation of ERBB1, insulin receptor, and the ERK1/2 and
AKT pathways in primary rodent hepatocytes. DCA-and TDCA-induced receptor and …
inactivation of protein tyrosine phosphatases (PTPases) and activation of ERBB1 and the
extracellular-regulated kinase (ERK) 1/2 pathway. The present studies have determined the
biochemical mechanism (s) through which these events occur. DCA and taurodeoxycholic
acid (TDCA)(100 μmol/L) caused activation of ERBB1, insulin receptor, and the ERK1/2 and
AKT pathways in primary rodent hepatocytes. DCA-and TDCA-induced receptor and …