[HTML][HTML] Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to …
Bile acid metabolism plays an essential role in cholesterol homeostasis and is critical for the
initiation of atherosclerotic disease. However, despite the recent advances, the molecular
mechanisms whereby bile acids regulate gene transcription and cholesterol homeostasis in
mammals still need further investigations. Here, we show that bile acids suppress
transcription of the gene (CYP7A1) encoding cholesterol 7α-hydroxylase, the rate-limiting
enzyme in bile acid biosynthesis, also through an unusual mechanism not involving the bile …
initiation of atherosclerotic disease. However, despite the recent advances, the molecular
mechanisms whereby bile acids regulate gene transcription and cholesterol homeostasis in
mammals still need further investigations. Here, we show that bile acids suppress
transcription of the gene (CYP7A1) encoding cholesterol 7α-hydroxylase, the rate-limiting
enzyme in bile acid biosynthesis, also through an unusual mechanism not involving the bile …