Adipose tissue has evolved as a complex organ with functions far beyond the mere storage
of energy. Chronic oversupply of calories, common to Western-style diets, frequently goes
hand-in-hand with an altered secretion pattern of adipokines and elevated plasma free fatty
acid levels, known to modulate insulin sensitivity in skeletal muscle. Intramyocellular
accumulation of lipids directly attenuates insulin signaling within myocytes via distinct
kinases. Obesity is also accompanied by an enhanced basal inflammatory tone, originating …