Agrin-Induced Postsynaptic-like Apparatus in Skeletal Muscle Fibersin Vivo
I Cohen, M Rimer, T Lømo, UJ McMahan - Molecular and Cellular …, 1997 - Elsevier
We find that when extrajunctional regions of denervated soleus muscles in adult rats are
transfected with cDNA encoding rat agrin isoform Y4Z8, which is normally secreted by motor
neurons at adult neuromuscular junctions, the myofibers express and secrete the neural
agrin. Muscle fibers in the vicinity of transfection form at their surface specialized areas
having extracellular, plasma membrane, and cytoplasmic protein aggregates, narrow and
deep plasma membrane infoldings, and an accumulation of myonuclei, all of which are …
transfected with cDNA encoding rat agrin isoform Y4Z8, which is normally secreted by motor
neurons at adult neuromuscular junctions, the myofibers express and secrete the neural
agrin. Muscle fibers in the vicinity of transfection form at their surface specialized areas
having extracellular, plasma membrane, and cytoplasmic protein aggregates, narrow and
deep plasma membrane infoldings, and an accumulation of myonuclei, all of which are …