Angiotensin converting enzyme blockade and thirst
R Dinicolantonio - Clinical and Experimental Hypertension. Part A …, 1984 - Taylor & Francis
R Dinicolantonio
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1984•Taylor & FrancisAngiotensin I1 (AII) administered at levels encountered physiologically causes water replete
animals to drink (1). However the role of endogenous A11 in the control of drinking is not
clear (2). While the angiotensin converting enzyme (ACE) inhibitors attenuate drinking due
to caval ligation (3) little evidence suggests that A11 plays a role in drinking due to water
deprivation (4, 5). In the present study an examination has been made of the effect of the
potent, newly available ACE inhibitors m421 & MK422 (6) on drinking due to water …
animals to drink (1). However the role of endogenous A11 in the control of drinking is not
clear (2). While the angiotensin converting enzyme (ACE) inhibitors attenuate drinking due
to caval ligation (3) little evidence suggests that A11 plays a role in drinking due to water
deprivation (4, 5). In the present study an examination has been made of the effect of the
potent, newly available ACE inhibitors m421 & MK422 (6) on drinking due to water …
Angiotensin I1 (AII) administered at levels encountered physiologically causes water replete animals to drink (1). However the role of endogenous A11 in the control of drinking is not clear (2). While the angiotensin converting enzyme (ACE) inhibitors attenuate drinking due to caval ligation (3) little evidence suggests that A11 plays a role in drinking due to water deprivation (4, 5). In the present study an examination has been made of the effect of the potent, newly available ACE inhibitors m421 & MK422 (6) on drinking due to water deprivation in the rat. The diacid fom, MK422 is active both centrally and peripherally whereas the ester, MK421 requires hydrolysis to the active form (6).
Taylor & Francis Online