[HTML][HTML] Glia-and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference
S Morimoto, MD Cassell, CD Sigmund - Journal of Biological Chemistry, 2002 - ASBMB
The purpose of this study is to examine the regulation of blood pressure and fluid and
electrolyte homeostasis in mice overexpressing angiotensin II (Ang-II) in the brain and to
determine whether there are significant physiologic differences in Ang-II production in
neurons or glia. Therefore, we generated and characterized transgenic mice overexpressing
human renin (hREN) under the control of the glial fibrillary acidic protein (GFAP) promoter
(GFAP-hREN) and synapsin-I promoter (SYN-hREN) and bred them with mice expressing …
electrolyte homeostasis in mice overexpressing angiotensin II (Ang-II) in the brain and to
determine whether there are significant physiologic differences in Ang-II production in
neurons or glia. Therefore, we generated and characterized transgenic mice overexpressing
human renin (hREN) under the control of the glial fibrillary acidic protein (GFAP) promoter
(GFAP-hREN) and synapsin-I promoter (SYN-hREN) and bred them with mice expressing …